IL-33 与低灌注在脑白质高信号机制中的研究进展

玥莹 韩, 晓璇 张

摘要


脑白质高信号（White Matter Hyperintensities，WMH）是脑小血管病的主要影像学指标，由于其起病隐匿，容易被临床医生忽视，但随着疾病进展，患者可逐渐出现认知功能下降、步态障碍、二便失禁、缺血性卒中等。目前普遍认为年龄和高血压是脑白质高信号的最主要的危险因素，但对于其主要的机制，存在较多争议，目前认为其发生、发展可能是多方因素的结果。这篇综述通过讨论脑白质高信号各个机制之间的相互关系，并对脑白质高信号发病机制中炎症及低灌注的具体机制提供最新数据并进行综述。

关键词


脑白质高信号；IL-33；低灌注

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参考


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DOI: https://doi.org/10.12346/pmr.v4i6.7950

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