GITR/GITRL 在动脉粥样硬化中的研究进展

志敏 张, 征 马, 杰 张, 祖英 靳, 亮 赵

摘要


动脉粥样硬化是一种由脂质异常驱动的慢性炎症性疾病，是大多数心血管疾病的根本原因，免疫系统在其中起着重要作用。免疫检查点蛋白是免疫反应的关键调节剂。近年来的多项研究证实，糖皮质激素诱导的肿瘤坏死因子受体（glucocorticoid-induced TNF receptor，GITR）作为一种共刺激免疫检查点蛋白，可与其天然配体（GITR ligand，GITRL）结合，驱动动脉粥样硬化的发生。监测血清 GITR 含量并及时采取干预治疗措施具有极其重要的意义。论文对 GITR-GITRL 二元组与机体免疫及动脉粥样硬化的关系进行了综述。

关键词


GITR；GITRL；动脉粥样硬化

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参考


GBD 2019 Stroke Collaborators[J].Lancet Neurol, 2021 Oct;20(10):795-820.

Tabas I, Lichtman AH. Monocyte-Macrophages and T Cells in Atherosclerosis[J]. Immunity, 2017 Oct 17;47(4):621-634.

Yusuf S, Bosch J, Dagenais G, et al. Cholesterol Lowering in Intermediate-Risk Persons without Cardiovascular Disease[J]. N Engl J Med, 2016 May 26;374(21):2021-31.

Shami A, Atzler D, Bosmans LA, et al. Glucocorticoid-induced tumour necrosis factor receptor family-related protein (GITR) drives atherosclerosis in mice and is associated with an unstable plaque phenotype and cerebrovascular events in humans[J]. Eur Heart J, 2020 Aug 14;41(31):2938-2948.

何宇,贾继东,王萍.糖皮质激素诱导的肿瘤坏死因子受体相 关蛋白及其配体在肝脏疾病中的作用[J].临床肝胆病杂志, 2021,37(7):1718-1723.

Bosmans LA, Shami A, Atzler D, et al. Glucocorticoid induced TNF receptor family-related protein (GITR) - A novel driver of atherosclerosis[J]. Vascul Pharmacol, 2021 Aug;139:106884.

Mollica V, Di Nunno V, Gatto L, et al. Novel Therapeutic Approaches and Targets Currently Under Evaluation for Renal Cell Carcinoma: Waiting for the Revolution[J]. Clin Drug Investig, 2019 Jun;39(6):503-519.

Kanamaru F, Youngnak P, Hashiguchi M, et al. Costimulation via glucocorticoid-induced TNF receptor in both conventional and CD25+ regulatory CD4+ T cells[J]. J Immunol, 2004 Jun 15;172(12):7306-14.

Ronchetti S, Nocentini G, Bianchini R, et al. Glucocorticoid- induced TNFR-related protein lowers the threshold of CD28 costimulation in CD8+ T cells[J]. J Immunol, 2007 Nov 1;179(9):5916-26.

Oja AE, Brasser G, Slot E, et al. GITR shapes humoral immunity by controlling the balance between follicular T helper cells and regulatory T follicular cells[J]. Immunol Lett, 2020 Jun;222:73-79. [11] Fu Z, Wang S, Li J, et al. Biological role of GITR/GITRL in attributes and immune responses of macrophage[J]. J Leukoc Biol, 2020 Feb;107(2):309-321.

Kim WJ, Bae EM, Kang YJ, et al. Glucocorticoid-induced tumour necrosis factor receptor family related protein (GITR) mediates inflammatory activation of macrophages that can destabilize atherosclerotic plaques[J]. Immunology, 2006 Nov;119(3): 421-429.

童辉煜,黄裕立,胡允兆.基质金属蛋白酶9在动脉粥样硬化中的 研究进展[J].中国动脉硬化杂志,2016,24(8):855-859.

程凯,周进,陈燕,等.免疫检查点抑制药相关不良事件对疗效预 测的研究现状[J].中国临床药理学杂志,2022,38(21):2648-2651.




DOI: https://doi.org/10.12346/pmr.v4i6.7931

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