胎龄≤32周早产儿支气管肺发育不良影响因素的研究

心悦 陈, 力敏 高, 利蕊 刘, 美茜 王, 彦秋 武

摘要


目的：探讨胎龄 ≤32 周早产儿发展为支气管肺发育不良（BPD）影响因素。方法：收集某院胎龄 ≤32 周早产儿的 临 床 资 料 并 分 析。 结 果： 母 亲 患 绒 毛 膜 羊 膜 炎（OR=3.393,95%CI：1.434-8.030）、 出 生 体 重 量 ＜ 1250g（OR=2.189，95%CI：1.029~4.656）、有创辅助通气时长＞ 7 天（OR=2.968，95%CI：1.266~6.957）、生后早期使用抗生素使用时长＞ 7 天（OR=2.753,95%CI：1.300~5.832）是 BPD 的独立危险因素，居住城市（OR=0.413，95%CI：0.205~0.833）为保护因素。结论：预防孕期宫内感染、增加出生体重、提升居住环境、合理控制抗生素使用时长及有创呼吸支持均有利于减少 BPD 的发生。

关键词


支气管肺发育不良；胎龄 ≤32 周；早产儿；抗生素

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参考


邵肖梅,叶鸿瑁,丘小汕.实用新生儿学[M].第5版.北京:人民卫生 出版社,2019.

Stoll BJ, Hansen NI, Bell EF, et al. Trends in Care Practices, Morbidity, and Mortality of Extremely Preterm Neonates, 1993- 2012.[J].JAMA. 2015,314(10):1039-1051.

Lui K, Lee SK, Kusuda S, et al. Trends in outcomes for neonates born very preterm and very low birth weight in 11 high-income countries[J]. The Journal of Pediatrics, 2019,215:32-40.

Chawanpaiboon S, Vogel JP, Moller A-B, et al. Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis[J]. The Lancet Global Health,2019,7(1):37-46.

魏红玲,邢燕,武慧,等.支气管肺发育不良早产儿婴儿期预后研 究[J].中国当代儿科杂志,2019,21(7):624-628.

O’Reilly M, Sozo F, Harding R. Impact of preterm birth and bronchopulmonary dysplasia on the developing lung: long-term consequences for respiratory health[J]. Clin Exp Pharmacol Physiol,2013,40(11):765-773.

Novitsky A, Tuttle D, Locke RG, et al. Prolonged early antibiotic use and bronchopulmonary dysplasia in very low birth weight infants[J]. American journal of perinatology,2015,32(1):43-48.

Joseph B. Cantey, Landon W. Huffman, Abirami Subramanian, et al. Antibiotic Exposure and Risk for Death or Bronchopulmonary Dysplasia in Very Low Birth Weight Infants[J]. The Journal of Pediatrics,2017(181):289-293.

Ran Xiao, He Yu, Ai Qing, et al. Effect of antibiotic- induced intestinal dysbacteriosis on bronchopulmonary dysplasia and related mechanisms[J]. Journal of translational medicine,2021,19(1):155.

Viscardi RM. Perinatal inflammation and lung injury[J]. Seminars in fetal & neonatal medicine,2012,17(1):30-35.

Wang Lan-Wan. Identifying Risk Factors Shared by Bronchopulmonary Dysplasia, Severe Retinopathy, and Cystic Periventricular Leukomalacia in Very Preterm Infants for Targeted Intervention[J]. Neonatology,2018,114(1):17-24.

Metcalfe A, Lisonkova S, Sabr Y, et al. Neonatal respiratory morbidity following exposure to chorioamnionitis[J]. BMC Pediatrics,2017,17(1):128.

Hütten MC, Kramer BW. Patterns and etiology of acute and chronic lung injury: insights from experimental evidence[J]. Chinese journal of contemporary pediatrics, 2014,16(5):448-459.

Thomas W, Speer CP. Chorioamnionitis is essential in the evolution of bronchopulmonary dysplasia--the case in favour[J]. Paediatric Respiratory Reviews,2014,15(1):49-52.

Deschamps J, Boucekine M, Fayol L, et al. Neighborhood Disadvantage and Early Respiratory Outcomes in Very Preterm Infants with Bronchopulmonary Dysplasia[J]. The Journal of pediatrics,2021(237):177-182.




DOI: https://doi.org/10.12346/pmr.v4i3.6680

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