细胞因子信号抑制因子3与神经系统及相关疾病文献综述

楠 吴, 高源 李

摘要


细胞因子信号抑制因子 3（SOCS3）是一种由 SOCS3 基因编码的蛋白。该蛋白表达及功能的异常同自身免疫病、代谢失调、肿瘤等多种疾病的发生发展相关。该基因编码了 STAT 诱导的 STAT 抑制剂（SSI）家族成员，即细胞因子信号抑制因子（SOCS）。SSI家族成员是细胞因子诱导的细胞因子信号负调控因子。SOCS3 与中枢神经系统及相关疾病有密切关系，论文主要围绕 SOCS3 的结构功能及与中枢神经系统的关系展开。

关键词


SOCS3；STAT3；CNS

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参考


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DOI: https://doi.org/10.12346/pmr.v3i5.4490

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