Analysis of Anti-infective Treatment and Monitoring of Adverse Reactions in a Case of Pulmonary Infection with Multidrug Resistant Acinetobacter Baumannii

Han Fang, Zhe Wang

Abstract


Objective: To discuss the characteristics of anti-infection treatment of multidrug-resistant acinetobacter bau- mannii in pulmonary infection and the necessity of pharmaceutical care. Methods: Taking a case of pneumonia with multidrug-resistant acinetobacter baumannii indicated by pulmonary alveolar lavage fluid as an example, which was treated by clinical pharmacists in the form of consultation. And expounding the importance of rational use of antibiotics and characteristics of pharmaceutical care by referring to literature and pharmacokinetics. Results: Multidrug-resistant acinetobacter baumannii was found by alveolar lavage after admission, and the infection symptoms were not effec- tively controlled after tigecycline treatment. With the consultation assistance of clinical pharmacists, it was found that the patient had low albumin, which had a great influence on tigecycline with high protein binding rate. Later, cefoper- azone sulbactam + tigecycline was used on the premise of albumin supplementation. That is recommended by clinical pharmacists. One week later, the patient’s symptoms improved and were discharged. During the treatment, the clinical pharmacist took pharmaceutical care of the patient, timely solved the adverse reaction of vomiting in the early stage of medication, and solved the concerns of doctors. Conclusions: In the case of pulmonary infection with multidrug-resist- ant Acinetobacter baumannii, not only the drug sensitivity list, we should also refer to the pharmacokinetics of drugs and monitor the adverse reactions of drugs in the process of treatment, which has a certain positive significance for the scientific use of antibiotics.

Keywords


Acinetobacter baumannii; Antiinfective therapy; Clinical pharmacist; Pharmacokinetics

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DOI: https://doi.org/10.12346/jnp.v2i1.6285

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