关于生长分化因子 15（GDF15）的研究进展

春蕊 任, 建凤 刘

摘要


生长分化因子 15（Growth differentiation factor，GDF15）是一种肽类激素，是转化生长因子 β（TGFβ）超家族的分化成员。在正常生理学中，GDF15 以低浓度在多个组织中表达，在许多病理条件下（如组织损伤和炎症）过度表达，发挥保护作用。GDF15 水平升高与肥胖、糖尿病、非酒精性脂肪性肝病和甲状腺相关疾病等有关，GDF15 在许多疾病中具有作为疾病生物标志物的潜在价值。本综述总结了近年来国际上 GDF15 的相关进展，有助于更好地认识该因子与临床部分常见疾病的相关性。

关键词


生长分化因子 15；肥胖；糖尿病；非酒精性脂肪性肝病

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参考


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DOI: https://doi.org/10.12346/pmr.v5i3.8526

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