低密度脂蛋白亚型与急性脑梗死的相关性研究

亚晨 李, 广玉 张

摘要


急性脑梗死（ACI）的发病随着人口的增加随之增加，在中国死亡疾病中居于首位。脑梗死的危险因素繁杂，主要原因是头颈动脉粥样硬化及栓子的形成。动脉粥样硬化主要是血脂水平的改变，血脂中以低密度脂蛋白（LDL）为主。低密度脂蛋白分为 7 个亚型，其中 LDL1-2 转运正常的胆固醇，LDL3-7 易于氧化，携带胆固醇容易沉积在血管壁上形成斑块，有研究显示 LDL3-7 可以使心血管疾病的发生、发展的风险增高 3 倍以上，有学者通过 LDL 的研究发现 LDL3-7 作为预测 ACI的指标比 LDL 更敏感。论文就 LDL 各亚型和急性脑梗死的相关性研究作一综述，分别从 LDL 各亚型的生成、分离检测方法及其作用与脑梗死的关系及治疗药物等方面进行阐述。

关键词


急性脑梗死；血脂异常；低密度脂蛋白

全文:

PDF

参考


Wu S, Wu B, Liu M, et al. Stroke in China: advances and challenges in epidemiology, prevention, and management[J]. Lancet Neurol, 2019,18(4):394-405.

Klapak D, Broadfoot S, Penner G, et al. Development of novel aptamers for low-density lipoprotein particle quantification[J]. PLOS ONE, 2018,13(10):205460.

米春芳,刘庆平.血浆低密度脂蛋白和高密度脂蛋白亚 组分的临床意义

梁菊萍,杨旸,董继存.急性脑梗死患者流行病学调查

Langsted A, Nordestgaard B G, Kamstrup P R. Elevated Lipoprotein(a) and Risk of Ischemic Stroke[J]. Journal of the American College of Cardiology, 2019,74(1):54-66.

Ference B A, Ginsberg H N, Graham I, et al. Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel[J]. European Heart Journal, 2017,38(32): 2459-2472.

Srisawasdi P, Vanavanan S, Rochanawutanon M, et al. Heterogeneous properties of intermediate- and low-density lipoprotein subpopulations[J]. Clinical Biochemistry, 2013,46(15):1509-1515.

Hoogeveen R C, Gaubatz J W, Sun W, et al. Small dense low- density lipoprotein-cholesterol concentrations predict risk for coronary heart disease: the Atherosclerosis Risk In Communities (ARIC) study[J]. Arterioscler Thromb Vasc Biol, 2014,34(5): 1069-1077.

杨海涛,谢翔.低密度脂蛋白亚组分与冠心病的研究进展[J].医 学综述,2017,23(13):2563-2566.

Ai M, Otokozawa S, Asztalos B F, et al. Small Dense LDL Cholesterol and Coronary Heart Disease: Results from the Framingham Offspring Study[J]. Clinical Chemistry, 2010, 56(6): 967-976.

Sumino H, Nakajima K, Murakami M. Possibility of New Circulating Atherosclerosis-Related Lipid Markers Measurement in Medical and Complete Medical Checkups: Small Dense Low- Density Lipoprotein Cholesterol and Lipoprotein Lipase[J]. Rinsho Byori, 2016,64(3):298-307.

Musunuru K, Strong A, Frank-Kamenetsky M, et al. From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus[J]. Nature, 2010,466(7307):714-719.

杨海涛,谢翔.低密度脂蛋白亚组分与冠心病的研究进展[J].医 学综述,2017,23(13):2563-2566.

Chung M, Lichtenstein A H, Ip S, et al. Comparability of methods for LDL subfraction determination: A systematic review[J]. Atherosclerosis, 2009,205(2):342-348.

Krauss R M, Pinto C A, Liu Y, et al. Changes in LDL particle concentrations after treatment with the cholesteryl ester transfer protein inhibitor anacetrapib alone or in combination with atorvastatin[J]. Journal of Clinical Lipidology, 2015,9(1):93-102.

Williams P T, Zhao X, Marcovina S M, et al. Comparison of four methods of analysis of lipoprotein particle subfractions for their association with angiographic progression of coronary artery disease[J]. Atherosclerosis, 2014,233(2): 713-720.

Bañuls C, Bellod L, Jover A, et al. Comparability of two different polyacrylamide gel electrophoresis methods for the classification of LDL pattern type[J]. Clinica Chimica Acta, 2012,413(1-2): 251-257.

Pathak M, Chaudhary N, Rathore A S. Development of a low- cost, high-throughput native polyacrylamide gel electrophoresis (N-PAGE) protocol for lipoprotein sub-fractionation using Quality by Design approach[J]. Journal of pharmaceutical and biomedical analysis, 2014,92:119-126.

孙浩行,汪骅,王长城,等.低密度脂蛋白亚组分

刘广彬,龚开政,张振刚,等.老年患者血浆低密度脂蛋白亚型分 布特点[J].中华老年心脑血管病杂志,2019,21(3):232-235.

刘广彬,夏光伟,龚开政,等.成人低密度脂蛋白亚型与颈动脉内膜中膜厚度的关系[J].中国动脉硬化杂志,2018,26(11):1154-1158.

Zitnanova I, Siarnik P, Fullop M, et al. Gender differences in LDL- and HDL-cholesterol subfractions in patients after the acute ischemic stroke and their association with oxidative stress markers[J]. J Clin Biochem Nutr, 2018,63(2):144-148.

舒伯辉,曹春艳,张灿飞,等.血清氧化型低密度脂蛋白水平与 大动脉粥样硬化性脑梗死患者中国缺血性卒中亚型分型和 神经功能缺损程度的相关性研究[J].实用心脑肺血管病杂志,2018,26(3):27-30.

刘焕琥,潘旭东,马爱军,等.急性脑梗死患者血清氧化型低密度脂蛋白水平变化

王龙,赵学敏,袁肖征,等.急性脑梗死患者血清促动脉硬化指数与颈动脉内膜中层厚度

Gluba-Brzózka A, Franczyk B, Banach M, et al. Do HDL and LDL subfractions play a role in atherosclerosis in end-stage renal disease (ESRD) patients?[J]. International urology and nephrology, 2017,49(1):155-164.

Duan R, Xue W, Wang K, et al. Estimation of the LDL subclasses in ischemic stroke as a risk factor in a Chinese population[J]. BMC Neurol, 2020,20(1):414.

Spence J D, Azarpazhooh M R, Larsson S C, et al. Stroke Prevention in Older Adults[J]. Stroke, 2020,51(12):3770-3777.

汪怡君,玄明文,张红旭,等.小而密低密度脂蛋白与颈动脉粥样硬化程度的相关性[J].中国现代医学杂志,2020,30(16):67-71.

程小兵,罗娟娟,陈燕,等.血清小而密低密度脂蛋白胆固醇、同 型半胱氨酸与颈动脉粥样硬化关系研究[J].中国循证心血管医学杂志,2021,13(2):173-177.

黄建,江钟立,沈璐.小而密低密度脂蛋白水平与他汀类药物剂量

Yao T, Long Q, Li J, et al. Small dense low-density lipoprotein cholesterol is strongly associated with NIHSS score and intracranial arterial calcification in acute ischemic stroke subjects[J]. Scientific Reports, 2020,10(1).

Zeljkovic A, Vekic J, Spasojevic-Kalimanovska V, et al. LDL and HDL subclasses in acute ischemic stroke: Prediction of risk and short-term mortality[J]. Atherosclerosis, 2010,210(2):548-554.

陈雅斌,蔡禾辉,张建明,等.血浆小而密低密度脂蛋白与缺血性 脑卒中的相关性[J].检验医学,2020,35(5): 409-413.

林彩红,方玲,吴华,等.低密度脂蛋白胆固醇控制目标值与颈动 脉斑块退缩的相关性研究[J].中国实用内科杂志,2021,41(7): 604-608.

梁赛杰,尹永坤,王丽娜.小而密低密度脂蛋白在缺血性脑 卒中不同剂量他汀类药物干预后的变化[J].心脑血管病防 治,2021,21(4):405-407.

文洪波,黄健康,姚义琴,等.阿托伐他汀钙与匹伐他汀钙对急性 脑梗死合并颈动脉粥样硬化斑块患者颈动脉斑块和血脂的影 响[J].海南医学,2021,32(12):1541-1544.

渠惠琳,徐瑞霞,张彦,等.匹伐他汀对动脉粥样硬化患者脂蛋白 颗粒和氧化型低密度脂蛋白的影响[J].中国分子心脏病学杂 志,2021,21(1):3703-3706.




DOI: https://doi.org/10.12346/pmr.v4i3.6702

Refbacks

  • 当前没有refback。