关于胰岛素样生长因子-1（IGF-1）的研究进展

潇光 许, 建凤 刘

摘要


由于重组人胰岛素样生长因子 -1（rhIGF-1）及牛初乳短链胰岛素样生长因子 -1（Bc-tIGF-1）的研制成功，促进了对 IGF-1 临床治疗作用的开发。IGF-1 是人体血液和组织液中广泛存在的具有促进生长作用的物质，它是人体内肝细胞、肾细胞、脾细胞等十几种细胞自分泌和旁分泌的产物，在人体内，IGF-1 通过 IGF-1 受体介导发挥其类胰岛素样促物质代谢作用。但是IGF-1 促进细胞分裂作用是一把双刃剑，一方面该作用可以保护受损组织，促进修复，另一方面则是增加了机体肿瘤发生的易感性。近来研究表明其与心血管系统、多脏器肿瘤、骨骼肌肉系统、神经精神疾病等均具有较强相关性，论文通过回顾近年来国际上对 IGF-1 的研究，概述了关于 IGF-1 的最新进展，有助于更好地认识和了解该因子与临床部分常见疾病的相关性。

关键词


IGF-1；心血管系统；骨骼肌肉系统；精神心理疾病；肿瘤

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参考


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DOI: https://doi.org/10.12346/pmr.v4i3.6699

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