不同剂量生长激素对青春期前ISS患儿的疗效及骨代谢影响分析

晨晴 高, 燕 王

摘要


目的：探讨不同剂量生长激素（rhGH）治疗对青春期前 ISS 患儿的疗效以及骨代谢影响的分析。方法：收集 70 例ISS 的临床资料，根据治疗剂量随机分为 3 组，分别予 0.15、0.18、0.20 IU/kg.d 不同 rhGH 治疗 12 个月。结果：大剂量组比小、中剂量组 HV、HtSDS 提升更为明显（P ＜ 0.05），三组患儿治疗后 OC、BAP 较治疗前活跃（P ＜ 0.05），比较显示小、大剂量组差异有统计学意义（P ＜ 0.05）。结论：rhGH 剂量越大促生长效果越明显，治疗后骨代谢水平明显较治疗前活跃。

关键词


重组人生长激素；特发性矮小；骨代谢；疗效

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参考


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DOI: https://doi.org/10.12346/pmr.v4i3.6682

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