脂肪因子METRNL、总胆红素水平与冠心病患者冠状动脉病变程度的相关性分析

兵兵 孟, 振江 丁, 华 樊

摘要


目的：探讨冠心病患者血清 METRNL、TBIL 水平与冠状动脉病变严重程度的相关性，以及对冠心病的临床预测价值。方法：选自 2019 年 7 月至 2020 年 1 月于某院行冠状动脉造影术检查符合纳入标准者 258 人，将入选患者按 Gensini 评分以三分位法分为高、中、低三组，分析 METRNL、TBIL 水平在各组间的差异及与 Gensini 评分的相关性。结果：对照组METRNL、TBIL 水平高于 CHD 组；METRNL、TBIL 水平与 Gensini 评分呈负相关（P ＜ 0.01），发现低 METRNL（＜ 149.48pg/mL）水平和低 TBIL（＜ 11.99umol/l）水平为 CHD 独立危险因素，通过绘制 ROC 曲线确定了 METRNL、TBIL 在预测 CHD发生的最优截断值分别是 161.7pg/mL、15.355umol/l，AUC 为 0.852、0.632。结论：冠心病患者血清 METRNL、TBIL 水平与冠状动脉病变程度密切相关，低 METRNL、TBIL 水平可作为 CHD 独立危险因素，对 CHD 有较高的预测价值。

关键词


冠心病；METRNL；总胆红素；Gensini 评分

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参考


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DOI: https://doi.org/10.12346/pmr.v4i3.6681

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