探讨血清CTRP9水平与维持性血液透析患者左心室肥厚的关系

昊洲 韩, 景福 王

摘要


目的：探讨维持性血液透析（MHD）患者左心室肥厚（LVH）与血清中补体 C1q/ 肿瘤坏死因子相关因子 9（CTRP9）水平的关系，以及其对 MHD 患者 LVH 的临床预测价值。方法：选自 2020 年 11 月至 2021 年 10 月在承德医学院附属医院规律进行血液透析治疗的患者 111 例。同时收集患者相关资料，完成超声心动图检查，计算左室质量指数（LVMI），将入选患者分为 LVH 组、非 LVH，分析 CTRP9 水平在各组间的差异及与 LVH 的相关性。结果：LVH 组 CTRP9 水平低于非 LVH组，CTRP9 水平与 LVH 呈负相关（r=-0.479，P ＜ 0.05），通过 logistics 回归分析，发现高水平血清 CTRP9 是 LVH 的独立保护因素 {OR=0.159，95%CI（0.059~0.428），P=0.000}，通过绘制 ROC 曲线确定了 CTRP9 在预测 LVH 发生的最优截断值为37.49pg/ml，曲线下面积为 0.795(P=0.000，95%CI:0.709~0.880)。结论：MHD 患者血清 CTRP9 水平与 LVH 密切相关，高水平血清 CTRP9 是 LVH 的独立保护因素，对 LVH 有一定的预测价值。

关键词


维持性血液透析；CTRP9；左心室肥厚

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参考


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DOI: https://doi.org/10.12346/pmr.v4i3.6675

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