CTRP家族在肾脏疾病中的研究进展

恒楠 黎, 桂才 胡

摘要


补体 C1q/ 肿瘤坏死因子相关蛋白（complemented-C1q/tumor necrosis factor-related protein，CTRP）家族是一类脂肪因子超家族，由脂肪组织分泌，在心脏、肾脏、肺、血管壁、胎盘、眼睛等不同组织中均有表达。目前，CTRP1~CTRP15 组成了 CTRP 家族，它们结构特征类似，与脂联素高度同源。CTRP 家族参与了代谢性疾病、动脉粥样硬化、妊娠相关疾病、慢性阻塞性肺疾病等多种疾病的发生发展。部分 CTRP 蛋白在这些疾病中起重要保护作用，应用重组 CTRP 蛋白或诱导 CTRP过表达或许能够减轻疾病的严重程度以及减缓疾病的发展进程。近年来研究发现，CTRP 家族与多种肾脏疾病如糖尿病肾病、急性肾损伤、原发性高血压肾损害等有些密切联系。

关键词


CTRP；肾脏疾病；糖尿病肾病；钙化

全文:

PDF

参考


Wong G W, Wang J, Hug C, et al. A family of Acrp30/adiponectin structural and functional paralogs[J]. Proc Natl Acad Sci U S A, 2004,101(28):10302-10307.

Ma R C W. Epidemiology of diabetes and diabetic complications in China[J]. Diabetologia, 2018,61(6):1249-1260.

安 ,卢艳敏,张 ,等.血清补体C1q/ 瘤坏死因子相关 白3水平对糖尿病 病代谢参数的影响及其 断价值研究[J].中国全 科医学,2020,23(26):3303-3310.

徐园园,任亚丽,卢学 ,等.糖尿病 病大鼠 组织中TGF-β1、 CTRP3的表 及相关性初探[J].微循环学杂志,2020,30(4):6-10.

Huynh P, Chai Z. Transforming growth factor β (TGFβ) and related molecules in chronic kidney disease (CKD)[J]. Clin Sci (Lond), 2019,133(2):287-313.

Fukuda N, Tahira Y, Matsuda H, et al. Transforming growth factor-beta as a treatment target in renal diseases[J]. J Nephrol, 2009,22(6):708-715.

Van Meeteren L A, Ten Dijke P. Regulation of endothelial cell plasticity by TGF-β[J]. Cell Tissue Res, 2012,347(1):177-186.

Wolf G, Ziyadeh F N. Molecular mechanisms of diabetic renal hypertrophy[J]. Kidney Int, 1999,56(2):393-405.

Zhang Z, Peng H, Chen J, et al. MicroRNA-21 protects from mesangial cell proliferation induced by diabetic nephropathy in db/db mice[J]. FEBS Lett, 2009,583(12):2009-2014.

梁子 ,朱艳,任 卓,等.CTRP3 Sirt1参与 糖条件下 小管细 的 固 转 [J].中国细 生物学学报,2019, 41(11):2108-2115.

Hu T Y, Li L M, Pan Y Z. CTRP3 inhibits high glucose-induced

Derakhshanian H, Shab-Bidar S, Speakman J R, et al. Vitamin

Wang Y, Deb D K, Zhang Z, et al. Vitamin D receptor signaling

童梦霞,郭久畅,张琳,等.早期糖尿病肾病患者血清CTRP9水平

Miller R G, Mahajan H D, Costacou T, et al. A Contemporary Estimate of Total Mortality and Cardiovascular Disease Risk in Young Adults With Type 1 Diabetes: The Pittsburgh Epidemiology of Diabetes Complications Study[J]. Diabetes Care,

姚希,张凯旋.血清Apelin和补体C1q肿瘤坏死因子相关蛋白9与

Xiang H, Xue W, Li Y, et al. C1q/TNF-related protein 6 (CTRP6)

Fan R H, Zhu X M, Sun Y W, et al. CTRP6 inhibits fibrogenesis in TGF-β1-stimulated human dermal fibroblasts[J]. Biochem Biophys Res Commun, 2016,475(4):356-360.

Lei H, Wu D, Wang J Y, et al. C1q/tumor necrosis factor- related protein-6 attenuates post-infarct cardiac fibrosis by targeting RhoA/MRTF-A pathway and inhibiting myofibroblast differentiation[J]. Basic Res Cardiol, 2015,110(4):1-17.

Strutz F, Zeisberg M, Renziehausen A, et al. TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2)[J]. Kidney Int, 2001,59(2):579-592.

Huang W, Xu C, Kahng K W, et al. Aldosterone and TGF-beta1 synergistically increase PAI-1 and decrease matrix degradation in rat renal mesangial and fibroblast cells[J].Am J Physiol Renal Physiol, 2008,294(6):1287-1295.

Zeisberg M, Bonner G, Maeshima Y, et al. Renal fibrosis: collagen composition and assembly regulates epithelial-mesenchymal transdifferentiation[J]. Am J Pathol, 2001,159(4):1313-1321.

Huang J S, Chuang C T, Liu M H, et al. Klotho attenuates

Bai X, Hou X, Tian J, et al. CDK5 promotes renal tubulointerstitial fibrosis in diabetic nephropathy via ERK1/2/PPARγ pathway[J]. Oncotarget, 2016,7(24):36510-36528.

Sun S, Ning X, Zhai Y, et al. Egr-1 mediates chronic hypoxia- induced renal interstitial fibrosis via the PKC/ERK pathway[J]. Am J Nephrol, 2014,39(5):436-448.

Pat B, Yang T, Kong C, et al. Activation of ERK in renal fibrosis after unilateral ureteral obstruction: modulation by antioxidants[J]. Kidney Int,2005,67(3):931-943.

Caraci F, Gili E, Calafiore M, et al. TGF-beta1 targets the GSK- 3beta/beta-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts[J]. Pharmacol Res, 2008,57(4):274-82.

Wang S, Sun Z, Yang S, et al. CTRP6 inhibits cell proliferation and ECM expression in rat mesangial cells cultured under TGF- β1[J]. Biomed Pharmacother, 2018,97(1):280-285.

Gómez H, Kellum J A. Sepsis-induced acute kidney injury[J]. Curr Opin Crit Care, 2016,22(6):546-553.

Yagmur E, Buergerhausen D, Koek G H, et al. Elevated CTRP1 Plasma Concentration Is Associated with Sepsis and Pre-Existing Type 2 Diabetes Mellitus in Critically Ill Patients[J]. Journal of Clinical Medicine, 2019,8(5):661.

Li R, Yang X, Yu Y, et al. C1q/tumor necrosis factor related protein 6 (CTRP6) is involved in gentamicin-induced acute kidney injury in rats[J]. Chinese Journal of Cellular & Molecular Immunology, 2016,32(11):1458.

安丽丽.血清CTRP5水平与原发性高血压患者早期肾损害的相 关性研究[D].石家庄:河北医科大学,2017.

秦霄玥.原发性高血压患者血浆CTRP9水平与早期肾损害的相 关性研究[D].石家庄:河北医科大学,2020.

王瑾瑜,周允,冯寒,等.脂肪因子CTRP3促进血管钙化机制研究 [J].中国病理生理杂志,2012,28(11):2033.

周鹏.CTRP9在血管中膜钙化中的作用机制及药物干预研究 [D].济南:山东大学,2020.

Miyatake N, Adachi H, Nomura-Nakayama K, et al. Circulating CTRP9 correlates with the prevention of aortic calcification in renal allograft recipients[J]. PLoS One, 2020,15(1):1-14.




DOI: https://doi.org/10.12346/pmr.v3i6.4924

Refbacks

  • 当前没有refback。