乙肝病毒的治疗现状及其未来展望

卓轩 李, 梓健 郜

摘要


乙型病毒性肝炎是一种乙型肝炎病毒(HBV)所引起的,在全球传播广泛的传染病,且在中国有超过 9000 万感染者。论文通过对乙肝病毒各类治疗方法以及使用药物的调研,主要研究了干扰素和核苷类药物等抗病毒药物的作用以及当下的使用情况,同时对乙肝的药物治疗进行了展望。

关键词


乙肝;干扰素;核苷;治疗性疫苗;RNA 干扰

全文:

PDF

参考


王虹.药物抗病毒治疗慢乙肝的最新研究进展[J].黑龙江医 学,2021,45(13):1456-1457.

樊蓉,孙剑,侯金林.慢性乙型肝炎抗病毒治疗现状及展望[J].临 床肝胆病杂志,2016,32(11):2029-2032.

金丽,苏强,周建华,等.I型和III型干扰素抗病毒作用机制的研 究进展[J].中国生物制品学杂志,2021,34(4):481-486.

Marco De Andrea. The interferon system: an overview[J]. European Journal of Paediatric Neurology,2002(6):41-46.

郭素娟,李智伟.聚乙二醇与普通干扰素治疗HBeAg阳性慢性乙 型肝炎的疗效[J].肝脏,2016,21(2):119-122.

郑娟,刘威龙,舒丹,等.慢乙肝抗HBV病毒治疗的现状和研究进 展[J].热带医学杂志,2017,17(4):546-551.

王新军.长效干扰素与普通干扰素治疗慢性乙肝的成本—效果 比较[J].现代中西医结合杂志,2014,23(12):1300-1302.

Lampertico P, Vigan M, Di Costanzo Gg, et al. Ran-domised study comparing 48 and 96 weeks peginterferon α-2a therapy in genotype D HBeAg-negative chronic hepatitis B[J]. Gut,2013,62(2):290-298.

Wang C, Chen J, Sun J. Entecavir for treatment of lamivudine- refractory chronic hepatitis b[EB/OL]. Medical Journal of Chinese People’s Liberation Army. http://wprim.whocc.org. cn/admin/article/articleDetail?WPRIMID=563457&article Id=563457,1983-1-1.

Robinson, D M, Scott, et al. Entecavir[EB/OL]. Drugs. https:// link.springer.com/article/10.2165/00003495-200666120- 00009,2012-9-12.

European Association for the Study of the Liver. EASL clinical practice guidelines: management of chronic hepatitis B virus infec-tion[J]. J Hepatol,2012,57(1):167-185.

Liu MA. DNA vaccines: an historical perspective and view to the future[J]. Immunol Rev,2011,239(1):62-84.

杨富强,饶桂荣.乙型肝炎治疗性疫苗研究进展[J].传染病信 息,2015,28(2):65-69.

Xu DZ, Wang XY, Shen XL, et al. Results of a phase III clinical trial with an HBsAg-HBIG immunogenic complex therapeutic vac- cine for chronic hepatitis B patients: experiences and findings[J]. J Hepatol,2013,59(3):450-456.

Yang SH, Lee CG, Park SH, et al. Correlation of antiviral T-cell responses with suppression of viral rebound in chronic hepatitis B carriers: a proof-of-concept study[J]. Gene Ther,2006,13(14):1110- 1117.

Yang FQ, Yu YY, Wang GQ, et al. A pilot randomized controlled trial of dual-plasmid HBV DNA vaccine mediated by in vivo elec- troporation in chronic hepatitis B patients under lamivudine chem- otherapy[J]. J Viral Hepat,2012,19(8):581-593.

陈姝,兰英华,李用国.树突状细胞与乙肝慢性化的关系及树 突状细胞疫苗相关研究进展[J].国际免疫学杂志,2009,32(6): 446-449.

Qasim W, Brunetto M, Gehring AJ, et al. Immunotherapy of HCC metastases with autologous T cell receptor redirected T cells, tar-geting HBsAg in a liver transplant patient[J]. J Hepatol,2015,62(2):486-491.

Livingston BD, Alexander J, Crimi C, et al. Altered helper T lym-phocyte function associated with chronic hepatitis B virus infection and its role in response to therapeutic vaccination in humans[J]. J Immunol,1999,162(5):3088-3095.

Shi TD, Wu YZ, Jia ZC, et al. Therapeutic polypeptides based on HBV core 18-27 epitope can induce CD8+CTL-mediated cytoto-xicity in HLA-A2+human PBMCs[J]. World J Gastroenterol, 2004,10(13):1902-1906.

Hannon G J. RNA interference[J]. Nature,2002,418(6894):244-251. [22] Paddison P J, Caudy A A, Bernstein E, et al. Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells[J]. Genes Dev,2002,16(8):948-958.

Lee Y, Ahn C, Han J, et al. The nuclear RNase III Drosha initiates microRNA processing[J]. Nature,2003,425(6956):415-419.

Mocellin S, Costa R, Nitti D. RNA interference: ready to silence cancer?[J]. J Mol Med,2006,84(1):4-15.

Romano P R, McCallus D E, Pachuk C J. RNA interferencemediated prevention and therapy for hepatocellular carcinoma[J]. Oncogene,2006,25(27):3857-3865.

张学智,山长亮,叶丽虹,等.RNA干扰在抗乙肝治疗中的应用及其研究进展[J].生物化学与生物物理进展,2008(6):631-636.




DOI: https://doi.org/10.12346/pmr.v3i6.4887

Refbacks

  • 当前没有refback。