肾间质纤维化发病机制研究进展

全伟 程, 顺 陈, 跃红 严

摘要


慢性肾脏病（CKD）在世界上已经占据 10%~15% 的人口，与人类的健康和寿命息息相关。肾间质纤维化（RIF）是各种病因导致的慢性肾脏病进展为终末期肾脏病的共同的病理表现。炎症、梗阻、免疫或代谢性病变等导致肾脏损伤后启动纤维化过程，其病理特征主要为正常的肾间质和肾小管结构被大量聚集的细胞外基质（ECM）所代替而至 ECM 的合成和降解失衡及肾小管萎缩、微血管退化、肾组织慢性缺氧、瘢痕组织取代正常肾组织最终发展至肾衰竭。

关键词


肾间质；纤维化；发病机制

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参考


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DOI: https://doi.org/10.12346/pmr.v3i3.3743

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