Effect of Low Dose Lyophilized Recombinant Human Brain Natriuretic Peptide on Patients with Severe Heart Failure Complicated with Hypotension after Emergency PCI in Acute Anterior Wall AMI

Ni Chen, Yangjun He

Abstract


Objective: To study the effect of low-dose lyophilized recombinant human brain natriuretic peptide on pa- tients with severe heart failure complicated with hypotension after emergency PCI in acute anterior wall AMI. Meth- ods: 48 patients with severe heart failure complicated with hypotension after emergency percutaneous coronary inter- vention (PCI) for acute anterior myocardial infarction (AMI) from September 2020 to September 2021 were included in the study. They were randomly divided into reference group and study group, with 24 cases in each group. The refer- ence group was treated with general treatment, and the study group was treated with low-dose lyophilized recombinant human brain natriuretic peptide on the basis of the reference group. The brain natriuretic peptide, blood pressure and left ventricular ejection fraction of the two groups were observed before and after treatment. Results: The level of brain natriuretic peptide in the study group was lower than that in the reference group, the left ventricular ejection fraction was higher than that in the reference group, and the systolic and diastolic blood pressure were higher than that in the reference group (P < 0.05). The improvement effect of LVEDd (50.43 ± 6.87) mm and LVESD (45.37 ± 7.16) mm in the observation group was better than that in the control group (P < 0.05). The clinical treatment of 22 patients in the obser- vation group was effective, accounting for 91.67%, and that of 17 patients in the control group was effective, accounting for 70.83%, which was statistically significant (P < 0.05). Conclusions: The effect of low-dose lyophilized recombinant human brain natriuretic peptide in the treatment of patients with severe heart failure complicated with hypotension after emergency PCI of acute anterior wall AMI is satisfactory, which is helpful to improve cardiac function and hypotension symptoms.

Keywords


Lyophilized recombinant human brain natriuretic peptide; Acute anterior wall AMI; PCI; Heart failure; Hy- potension

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DOI: https://doi.org/10.12346/jnp.v2i1.6286

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