Correlation Analysis between Bacterial Drug Resistance Rate and Antimicrobial Use

Jing Chen

Abstract


Objective: To investigate the drug resistance rate of Acinetobacter baumannii and Klebsiella pneumoniae and carbapenem antibiotics in hospitalized patients in our hospital. Methods: The drug resistance rate of Acinetobacter baumannii and Klebsiella pneumoniae and the use of carbapenems in hospitalized patients in our hospital from January to September 2021 were studied (DDDs) were analyzed retrospectively, and the data were analyzed by Pearson correla- tion method. Results: The drug resistance rate of Acinetobacter baumannii to meropenem and biapenem in our hospital did not show significant correlation with their DDDs. The drug resistance rate of Klebsiella pneumoniae was also not significantly correlated with meropenem and biapenem DDDs. Conclusions: Acinetobacter baumannii was not found. The drug resistance rate of Klebsiella pneumoniae is related to the use of carbapenems. Our hospital should continue to control the application of drugs and delay the distribution and expansion of drug-resistant bacteria.

Keywords


Klebsiella pneumoniae; Acinetobacter baumannii; Carbapenems; Drug resistance rate; Correlation

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References


2019 national bacterial drug resistance monitoring report of the Expert Committee on rational drug use of the national health and Family Planning Commission, 2019. National bacterial resistance monitoring network.

Li, M., Lu, W.P., 2008. Analysis of distribution and drug resistance of Acinetobacter baumannii. Chongqing Medical Journal. 37(3), 264-265.

Hou, L.P., 2017. Analysis of carbapenem resistant gram negative bacilli. Journal of clinical laboratory (Electronic Edition). 6(04), 633-635.

Chinese Pharmacopoeia, 2009. Volume I. 3-159.

Chen, X.Q., Jin, Y.Y., Tang, G., 2011. New pharmacology. 17th edition, Beijing: People’s Health Publishing House. 34-105.

Liu, S.F., Cai, H., Yang, Y.J., et al., 2013. Research progress of grey correlation analysis model. System engineering theory and

Zhang, L., Pan, Y.J., Ma, A.L., et al., 2011. Grey correlation analy-sis and evaluation of proton pump inhibitors in a hospital. Chinese medical science. 17(1), 12-14.

Cao, J., Xu, H., E, M., et al, 2010. The drug sensitivity of Pseudo-monas aeruginosa was correlated with the frequency of cefopera- zone sulbactam and other antibiotics Chinese Journal of new drugs and clinical medicine. 29(1), 62-66.

Nai, J., Lin, H.N., Xia, F., et al., 2013. Study on drug resistance mechanism and multipoint sequence typing of carbapenem resis- tant Klebsiella pneumoniae. Laboratory medicine. 28(9), 862-863.




DOI: https://doi.org/10.12346/jnp.v2i1.6276

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